THUD!

That's the sound of the brick hitting the floor.

I have been asked to send in a FULL manuscript! I can't believe it!!

OK, deep breaths. There. Whew.

If I get no farther, this tells me a few things:
1) Your story needs to start off with a bang. Make sure you write a good, sharp hook.
2) Your query is important. It's your foot in the door. Make it as good as anything else you write.
3) A synopsis is a must. Some ask for it, some don't. Write it anyway, weed out the crap, and by all means include the ending.

Oh man, this is getting good.